I edited tiny webcam photos with three photo enlargement tools to compare the difference. The three contenders are Adobe Photoshop, Alien Skin Blow Up and TopazLabs Gigapixel AI.
For Photoshop I set the resolution to 300, and scaled up six times the original size (1920×1440 pixels). I set my resample mode to Preserve Details (enlargement) and reduced the noise by 35%.
Below is my final image with color corrections applied and artifacts cloned out. It still isn’t a perfect photo, but considering the source, I’m quite happy with the result.